The MTHFR gene mutation affects everyone differently, and has been shown to be associated with numerous health conditions including cardiovascular disease and high cholesterol, ADHD, autoimmune ...
Background Methotrexate (MTX) is the drug used most frequently in the therapy of juvenile idiopathic arthritis (JIA). However, long-term treatment in children frequently leads to intolerance, with ...
From the Department of Internal Medicine (E.A.V., A.C.S.), Division of Human Genetics, The Ohio State University, Columbus, Ohio, and the Carolina Cardiovascular ...
From Hemophilia and Thrombosis Center and Clot Connect Program (www.clotconnect.org), University of North Carolina School of Medicine, Chapel Hill (S.M.); Division of Hematology/Oncology/Bone Marrow ...
Background Methylene tetrahydrofolate reductase (MTHFR) deficiency is a rare autosomal recessive disorder, caused by mutated alleles of the MTHFR gene. Since this enzyme catalyzes the conversion of ...
Methylenetetrahydrofolate reductase (MTHFR) deficiency is a rare autosomal recessive inherited inborn error of metabolism, which presents with various severity ...
Individuals with MTHFR gene mutations often depend on Methylfolate supplements. These genetic changes can lead to a lack of folate, an essential nutrient that plays a crucial role in various body ...
Homocycteine is metabolized via two pathways, remethylation or trans-sulfuration. The former requires 5-methyltetrahydrofolate reductase (MTHFR) and Vitamin B12, the later requires ...